Archives by Month: July 2023
Oakwood Labs is proud to announce that we will be at the 2023 Controlled Release Society 2023 annual meeting and expo, July 24-28, 2023. The theme this year is “The Future of Delivery Science,” which focuses on the next generation of scientists and progressive research that is being conducted around the world.
Find Us at Booth 304
As a global leader in sustained-release drug delivery, Oakwood Labs is able to solve changes related to developing and manufacturing pharmaceutical injectables. We pride ourselves on being transparent with our clients throughout the whole process and offering our expertise. If you’re looking for state-of-the-art technology, personnel, and equipment, you’ll want to check out Oakwood Labs at booth #304.
We can help you with the following:
- Clinical trial manufacturing (Phase I, II, III)
- Feasibility studies
- Pre-formulation development activities
- Commercial aseptic GMB manufacturing
- Scale-up of formulation
- Manufacturing toxicology batches
- ICH compliant stability testing
Contact Us for More Information
The CRS 2023 conference covers a wide range of topics, and we are happy to contribute to the event! If you aren’t able to attend, but still want to learn more about Oakwood Labs or what you missed at the conference, contact us today!
We look forward to discussing our technology and more.
Amino acids have proven their capabilities in the pharmaceutical industry in a variety of ways. They can be used alone as nutritional supplements, synthesized to help form other products, or even built into drug delivery systems.
Since Oakwood Labs focuses on drug formulation, we wanted to explain the role of amino acids in pharmaceuticals, specifically addressing how they impact sustained-release injectables and provide therapeutic benefits to patients.
How Amino Acids Benefit Your Pharmaceutical Projects
Amino acids are used in the development and function of sustained-release injectables and pharmaceuticals because they help with matrix formulation, suspension, drug diffusion, and biocompatibility.
Different amino acids and combinations can be deployed to achieve specific therapeutic goals. With this in mind, the amino acids used will depend on factors like the drug that is being delivered, the intended release kinetics, and the compatibility of the overall formation.
Using amino acids in pharmaceuticals like sustained-release injectables assist with the following:
- Matrix formulation – The use of amino acids in sustained-release injectables can help form a matrix that is modified to perform long-acting therapy for the patient. The matrix encapsulates the active drug and helps control the rate at which it is released, making it ideal for less frequent doses and better patient compliance.
- Solubility – Solubility is needed in drug formulations because it leads to effective absorption. By enhancing the solubility of certain drugs, amino acids better maintain the composition of the drug and promote absorption into the body.
- Stability – Along with solubility, amino acids also protect the drug from degradation throughout the process of storage and release. Stabilization additionally helps increase drug effectiveness, especially when dealing with sustained-release applications.
- Modulation – Using amino acids in a sustained-release application can adjust the overall drug output to meet the demands of the patient. This means amino acids are capable of altering the diffusion characteristics of the drug being used within the formulation to better meet a patient’s therapeutic objectives.
- Biocompatibility – Amino acids used in pharmaceutical applications like sustained-release injectables can promote biocompatibility for medical applications. Biocompatibility means that the injectable will not interfere with any of the other cellular functions or compromise the patient’s wellness, and it is important because it increases safety, long-term tolerability, and regulatory compliance.
Benefits of Using Sustained-Release Pharmaceuticals
Sustained-release injectables and pharmaceuticals have gained popularity in recent years due to their variety of benefits. Since the drug remains active in the bloodstream over a period of time, sustained-release dosages offer prolonged therapeutic effects. This helps improve patient compliance and reduce the frequency of dosing.
Other advantages of sustained-release dosages include:
- Prolonged action of the medicaments
- Control over drug therapy
- Ability to modify the extent and rate of drug absorption
- Delivering API directly to the desired location
- Decreasing total amount of a drug, reducing local side effects
- Ability to modify the extent and rate of drug absorption
Work with Oakwood Labs on Your Next Project
If you are looking to incorporate amino acids into your pharmaceuticals, be sure to request help from the team at Oakwood Labs. We are a leading manufacturer of sustained-release pharmaceuticals and will work with you throughout the creation process. This includes proof of concept, feasibility studies, clinical trials, and finally the production of an FDA-approved commercial supply.
Additionally, our team has over 20 years of experience, which makes us a trusted and effective partner for global pharmaceutical firms of all sizes. See how we can incorporate amino acids into your sustained-release pharmaceuticals and beyond today.
Learn More About Using Amino Acids in Pharmaceuticals
The team at Oakwood Labs is ready to help you achieve high-quality results in your next project. Our quality assurance and validation practices will deliver the best solutions, regardless of the formulation needed.
For more information on using amino acids in sustained-release pharmaceuticals, be sure to contact us today.
In the pharmaceutical field, molecules are often a major topic since they play a key part in research and development. Small and large molecules each have their place, but small molecules are particularly significant in drug development since their size allows for easy passage through the gastrointestinal tract.
Benefits of Small Molecule Injectables
Small molecule pharmaceuticals are low molecular weight compounds that can be administered in a variety of ways, including via intravenous (IV), intramuscular (IM), or subcutaneous (SC) injections. In addition to offering various ways to inject medicine, small molecule injectables also provide benefits such as:
- Rapid onset of action – Small molecules are able to be absorbed quickly into the bloodstream, allowing them to provide needed assistance in emergency situations.
- Targeted delivery – These injectables can be formulated to target certain cells, increasing efficacy and reducing the potential for systemic side effects.
- High bioavailability – Small molecule injectables often can display high bioavailability, meaning a portion of the injected dose reaches the target organs or tissues. This ultimately reduces the need for higher doses, leads to lower costs, and can produce fewer side effects.
- Flexible dosing – By using injectables, more control over the dosage is possible. This allows for treatments to be adjusted based on patient needs.
- Stability and shelf life – Small molecule pharmaceuticals usually have a longer shelf life compared to other complex drug formulations. This is important when it comes to the storage and distribution of drugs.
- Potential for self-administration – These injectables can provide greater independence for patients, as some can be designed for self-administration.
- Improved patience compliance – In the event that a patient has trouble taking oral medication, these small molecule injectables provide a great alternative.
How Small Molecule Pharmaceuticals Play a Key Role in Medicine
With their ability to target specific areas in the body and provide therapeutic benefits, small molecule injectables have become a vital part of drug development and can be used for a variety of roles, such as in:
- Pharmacokinetic studies
- Post-marketing surveillance
- Clinical trials
- Regulatory approval
- Preclinical studies
- Formulation development
- High-throughput screenings
- Structure-activity relationship (SAR) studies
- Lead compound identification
- Target identification or validation
Small molecules have helped transform a wide range of medical conditions, making them an essential tool in the drug development process.
Where Oakwood Labs Steps In
Oakwood Labs has been an effective partner for a variety of pharmaceutical firms of diverse sizes. We pride ourselves on providing transparent communication, achieving milestones within set deadlines, and offering our expertise throughout the entire drug development process.
We have over 20 years of experience in developing sustained-release injectable pharmaceutical products, including small molecule injectables. Our team can help you if you are in the early development stages or are looking to scale up an existing formulation.
With state-of-the-art technology and dedicated personnel, we can help you solve all of your challenges, and our facilities are adept at handling small molecule injection manufacturing and more.
Our cGMP manufacturing facility is FDA-approved and was created to enhance our partnering and development capabilities. Features of our facility include:
- Aseptic filling
- In-house QC microbiology and QC chemistry
- Inspecting, labeling, and packaging
- Aseptic formulation
- Compact and portable equipment train
- Non-aseptic formulation
- Raw material dispensing and weighing
- Vial capping
- Shipping, receiving and warehouse space
- Aseptic pharmaceutical lyophilization
By working with us, you can expect benefits such as short lead times, robust quality systems, and CMC development capabilities for a wide selection of products.
Contact Oakwood Labs About Small Molecule Injection Manufacturing
If you’re interested in learning more about small molecule injection manufacturing, contact our team today. We are committed to developing products that provide therapeutic benefits to patients and excellent returns to our partners.